Linda Simmler: Changing synaptic strength

Changing synaptic strength: Psychedelics and their role in neuroplasticity

A free public lecture in English with Prof. Dr. Linda Simmler, hosted by the Psychedelic Research Organization of Zurich (PROZ).

About the talk

Clinical studies have shown that psychedelics such as psilocybin can reduce symptoms of depression after a single dose. What might explain these effects? Current evidence suggests that psychedelics can promote neuroplasticity in brain circuits implicated in depression. Preclinical studies have found that a single dose of psilocybin can lead to a lasting increase in the density of dendritic spines in the cortex. Studies have also found that psilocybin can strengthen synaptic connections.

In her talk, Prof. Dr. Linda Simmler will review the evidence for these changes in neurons and synapses and discuss how they might help explain the lasting therapeutic effects of psychedelics.

The evening includes a 45-minute lecture followed by 15 minutes of audience questions.

About the speaker

Prof. Dr. Linda Simmler leads the Neuropharmacology research group at the University of Basel. Her research examines how psychoactive substances affect synaptic plasticity, including the mechanisms underlying the antidepressant effects of psilocybin. She studied pharmacy and completed her PhD in pharmacology in Basel, then conducted research at Vanderbilt University and the University of Geneva. She will take up an assistant professorship with tenure track in pharmacology at the University of Zurich on 1 January 2027.

When and where

Tuesday, 17 November 2026 · 18:30
Universität Zürich · HAH-E-03
Häldeliweg 2, 8044 Zürich
Language: English · Admission: free (CHF 0)

Reserve your free ticket here on Eventfrog.

Event details on the PROZ website
Speaker profile: University of Basel